Cuatro amigos que regentan un pequeño bar en un barrio del sur de Philadelphia, la ciudad del amor fraternal, intentan mantener el equilibrio entre negocio y amistad, tarea nada fácil, ya que cada uno de ellos suele dejarse llevar únicamente por sus intereses personales, lo que desemboca en situaciones incómodas que amenazan con deteriorar sus relaciones personales.
Charlie and Dee have been stealing Frank's delicious meats, so Frank leaves out human meat to get back at them. Driven by their cannibalistic needs, Charlie and Dee go in search of human flesh. Mac and Dennis harass Frank for hunting defenseless animals and think it would be much more badass to hunt something that could fight back ... like a human.
Charlie, Mac, and Dennis formulate a plan to take advantage of the rising gas prices. By purchasing excess amounts now, they can sell it in the future and profit. As usual, things don't go as planned. Dee is also out to make money when she learns that Bruce is going to give the family fortune to a Muslim cultural center. She and Frank try to stop him and get the cash for themselves.
America’s Next Top Paddy’s Billboard Model Contest
Due to the gang's latest "business expenses," Paddy's is in dire need of money. Frank buys a billboard to advertise the bar, but Dee decides to create a viral video to post on YouTube for promotion. Charlie quickly joins her, leaving Frank and Mac to hold a contest for some hot models to feature on the billboard. Naturally, Dennis joins the competition to prove his worth.
Charlie finds out that the waitress has been seeing someone. He calls on Mac, his so-called best friend, to find out more information about the guy and to beat him up. However, it turns out that Mac is the guy the waitress has supposedly been seeing. Dennis, heartbroken that he's not Charlie's best friend, tries to win him over.
Charlie and Frank awake to find poop in their bed. Neither will confess to being the owner, so they, Mac, and Dennis try to scientifically deduce who dropped the deuce. Dee wants to do something a bit more sophisticated, so she invites the waitress and Artemis to a girls' night out.
After discovering Dennis' erotic memoir, Mac and Frank attempt to make some money off of it. Meanwhile, Dee and Charlie decide to spend a day in each other's shoes.
After Dee suffers a heart attack, she and Dennis try to live a healthier lifestyle. Meanwhile, Charlie and Mac take corporate jobs to get health insurance.
The gang fudge history by claiming that Paddy's Pub was responsible for cracking the Liberty Bell in an attempt to turn their dive into a Philadelphia landmark.
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