Cuatro amigos que regentan un pequeño bar en un barrio del sur de Philadelphia, la ciudad del amor fraternal, intentan mantener el equilibrio entre negocio y amistad, tarea nada fácil, ya que cada uno de ellos suele dejarse llevar únicamente por sus intereses personales, lo que desemboca en situaciones incómodas que amenazan con deteriorar sus relaciones personales.
Dennis, Mac, and Frank go into real estate, while Dee sets out to be a surrogate for a wealthy couple. Charlie gets into it with an attorney over the law.
The gang describes the trials and tribulations they went through, during game five of the World Series, in hopes the judge will clear them of all the citations they received.
The gang puts together a wrestling show for returning troops. Meanwhile, Dee finally meets the soldier that she has been communicating with over the internet.
After being banned for 10 years from a local drinking competition appropriately named "Flipadelphia," the gang tries to reignite their old rivalry with another local bar. Finding that they are in need of some serious practice, the guys head to Dennis' old fraternity house at the University of Pennsylvania to get their game up to speed while Dee hones her skills on her own. Frank wears skinny pants.
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