Cuatro amigos que regentan un pequeño bar en un barrio del sur de Philadelphia, la ciudad del amor fraternal, intentan mantener el equilibrio entre negocio y amistad, tarea nada fácil, ya que cada uno de ellos suele dejarse llevar únicamente por sus intereses personales, lo que desemboca en situaciones incómodas que amenazan con deteriorar sus relaciones personales.
Dennis and Dee's ailing grandfather Pop-Pop is wasting away in the hospital, and they have to decide whether or not to pull the plug. But things get complicated when The Gang learns of Pop-Pop's history as a Nazi, and Mac, Charlie and Frank set off in search of the old man's spoils from the war.
The Gang gets Freudian as they step into the therapist's office to work through their mountain of issues, but when Dennis thinks he has everyone figured out, the shrink turns the tables on him and exposes the insanity in his unique brand of pop psychology.
With Charlie under his wing, Frank cleans up so he can get his hands dirty and help out his old company with one last big merger. An unwritten rule of the bar gets the rest of the gang caught up in a case of mistaken identity.
Every member of The Gang has something to celebrate at Guigino's, Philly's finest eatery, but when Mac and Dennis' private dinner is interrupted by an unexpected sighting of Frank and Charlie, the in-fighting begins. Dee also turns up at a table for one, and over the course of the night, the "one-ups-manship" soars to new heights.
Court is in session at Paddy's Pub as Frank and Dennis present their cases to the rest of the gang, resulting in a verdict that will change their lives FOREVER... but not really.