Su mente es un misterio, sus métodos son un milagro.
La serie sigue a Shaun Murphy, un joven cirujano con autismo y síndrome del sabio de una pequeña ciudad, donde tuvo una infancia problemática. Él se traslada para unirse al prestigioso departamento de cirugía en San José St. Bonaventure Hospital.
Shaun and Lea get off to a bumpy start as new parents, while at work Shaun tries to navigate a problematic with one of the new residents he has to supervise: another doctor with Autism Spectrum DIsorder who idolizes him but also seems to "push all his buttons" by their very nature. Life hasn't run out of curveballs for Dr. Glassman, either, and it seems determined to force him to relive one of the hardest lessons he's yet refused to learn. Not all is bleak, though, as Drs. Park and Reznick take stock of their relationship and a chance reunion between Drs. Kalu and former team member Dr. Claire Brown soon has them entangled again as though no time had passed.
Un prodigioso cirujano con autismo y síndrome del sabio comienza a trabajar en un prestigioso hospital, donde se enfrenta al escepticismo de los pacientes y del personal.